One performance issue is to buy a High Availability (HA) solution like 
Mimix.  Run it on a different iSeries.  Have them run their queries to 
their hearts content over there.  Don't know if Sequel uses tiered 
pricing, but your HA machine is often less powered than your primary 
machine.  IBM gives you a discount on hardware if you buy it with a HA 
solution.
http://www-03.ibm.com/servers/eserver/iseries/hardware/is4ha/

Rob Berendt

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